Vascular hypercontractility to endothelin 1 in mice lacking endothelial PPARG
نویسندگان
چکیده
منابع مشابه
Progressive retinal degeneration in transgenic mice with overexpression of endothelin-1 in vascular endothelial cells.
PURPOSE Endothelin-1 (ET-1), synthesized in vascular endothelial cells, is a potent vasoconstrictor. ET-1-related vascular abnormality has been known to be important in the pathogenesis of glaucoma, especially in normal tension glaucoma. However, the long-term effect of increased vascular ET-1 on the retinal tissue is still unclear. METHODS The mice with overexpression of ET-1 in vascular end...
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ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2008
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.22.1_supplement.968.12